מחקרים ומאמרים במרכז סגול לרפואה היפרבארית (תא לחץ)

Performance and Aging

Hadanny Amir, Daniel-Kotovsky Malka, Suzin Gil, Boussi-Gross Rahav, Catalogna Merav, Dagan Kobi, Hachmo Yafit, Abu Hamed Ramzia, Sasson Efrat, Fishlev Gregory, Lang Erez, Polak Nir, Doenyas Keren, Friedman Mony, Tal Sigal, Zemel Yonatan, Bechor Yair, Efrati Shai.
Cognitive enhancement of healthy older adults using hyperbaric oxygen: a randomized controlled trial.
Aging. June 26, 2020

Amir Hadanny, Efrat Sasson, Laurian Copel, Malka Daniel-Kotovsky, Eldad Yaakobi, Erez Lang, Gregory Fishlev, Nir Polak, Mony Friedman, Keren Doenyas, Shachar Finci, Yonatan Zemel, Yair Bechor & Shai Efrati.
Physical enhancement of older adults using hyperbaric oxygen: a randomized controlled trial.
BMC Geriatrics, Volume 24, article number 572, (2024)

Yafit Hachmo, Amir Hadanny, Ramzia Abu Hamed, Malka Daniel-Kotovsky, Merav Catalogna, Gregory Fishlev, Erez Lang, Nir Polak, Keren Doenyas, Mony Friedman, Yonatan Zemel, Yair Bechor, Shai Efrati.
Hyperbaric oxygen therapy increases telomere length and decreases immunosenescence in isolated blood cells: a prospective trial. 
Aging. November 18, 2020

Karin Elman-Shina and Shai Efrati.
Ischemia as a common trigger for Alzheimer’s disease.
Aging Neuroscience. 26 September 2022

Ronit Shapira, Amos Gdalyahu, Irit Gottfried, Efrat Sasson, Amir Hadanny, Shai Efrati, Pablo Blinder, Uri Ashery.
Hyperbaric oxygen therapy alleviates vascular dysfunction and amyloid burden in an Alzheimer’s disease mouse model and in elderly patients.
Aging. September 9, 2021

Yafit Hachmo, Amir Hadanny, Sonia Mendelovic, Pnina Hillman, Eyal Shapira, Geva Landau, Hadar Gattegno, Avi Zrachya, Malka Daniel-Kotovsky, Merav Catalogna, Gregory Fishlev, Erez Lang, Nir Polak, Keren Doenyas, Mony Friedman, Yonatan Zemel, Yair Bechor, Shai Efrati.
The effect of hyperbaric oxygen therapy on the pathophysiology of skin aging: a prospective clinical trial.
Aging, September 16, 2021

Amir Hadanny, Relly Forer, Dina Volodarsky, Malka Daniel-Kotovsky, Merav Catalogna, Yonatan Zemel, Yair Bechor and Shai Efrati.
Hyperbaric oxygen therapy induces transcriptome changes in elderly: a prospective trial. Aging (Albany NY).
2021 Nov 30; 13(22): 24511–24523.

Amir Hadanny MD, Erez Lang MD, Laurian Copel MD, Oshra Meir MD, Yair Bechor MD, Gregory Fishlev MD, Jacob Bergan MD, Mony Friedman MD, Amnon Zisman MD & Shai Efrati MD.
Hyperbaric oxygen can induce angiogenesis and recover erectile function
International Journal of Impotence Research volume 30, pages292–299 (2018)

Marina Leitman, Shai Efrati, Shmuel Fuchs, Amir Hadanny & Zvi Vered
The effect of hyperbaric oxygenation therapy on myocardial function
The International Journal of Cardiovascular Imaging volume 36, pages833–840 (2020)

Shapira, R., B. Solomon, S. Efrati, D. Frenkel, and U. Ashery.
Hyperbaric Oxygen Therapy Ameliorates Pathophysiology of 3xtg-Ad Mouse Model by Attenuating Neuroinflammation.
Neurobiol Aging 62 (Feb 2018): 105-19.

Shapira, R., S. Efrati, and U. Ashery.
Hyperbaric Oxygen Therapy as a New Treatment Approach for Alzheimer’s Disease.
Neural Regen Res 13, no. 5 (May 2018): 817-18.

Amir Hadanny, Shai Efrati.
The Hyperoxic-Hypoxic Paradox.
Biomolecules. June 25, 2020

Amir Hadanny, Relly Forer Dina Volodarsky, Malka Daniel-Kotovsky , Merav Catalogna,
Yonatan Zemel, Yair Bechor , Shai Efrati.
Hyperbaric oxygen therapy induces transcriptome changes in elderly: a prospective trial.
Aging. November 24, 2021

Irit Gottfried, Nofar Schottlender and Uri Ashery.
Hyperbaric Oxygen Treatment – From Mechanisms to Cognitive Improvement. 
Biomolecules, 2021 Oct 15

Vadas, D., L. Kalichman, A. Hadanny, and S. Efrati.
Hyperbaric Oxygen Environment Can Enhance Brain Activity and Multitasking Performance.
Front Integr Neurosci 11 (2017): 25

Suzin G, Halpert Frolinger T, Yogev D, Hadanny A, Catalogna M, Rassovsky Y, Efrati S
Oxygen: The Rate-Limiting Factor for Episodic Memory Performance, Even in Healthy Young Individuals.
Biomolecules. 2020 Sep 17; 10(9):1328. doi: 10.3390/biom10091328

Maroon JC.
The effect of hyperbaric oxygen therapy on cognition, performance, proteomics, and telomere length-The difference between zero and one: A case report.
Front Neurol. 2022 Jul 29;13:949536. doi: 10.3389/fneur.2022.949536. eCollection 2022.PMID: 35968296

Amir Hadanny , Shai Efrati.
Editorial: Hyperbaric oxygen and the brain.
Front Neurol 2022 Dec 21; 13:1078544. doi: 10.3389/fneur.2022.1078544

Post-COVID 19 

Amir Hadanny, Shani Zilberman-Itskovich, Merav Catalogna, Karin Elman-Shina, Erez Lang, Shachar Finci, Nir Polak, Ran Shorer, Yoav Parag & Shai Efrati.
Long term outcomes of hyperbaric oxygen therapy in post covid condition: longitudinal follow-up of a randomized controlled trial.
Scientific Reports, volume 14, Article number: 3604 (2024), 15 February 2024

Marina Leitman, Shmuel Fuchs, Vladimir Tyomkin, Amir Hadanny, Shani Zilberman-Itskovich & Shai Efrati
The effect of hyperbaric oxygen therapy on myocardial function in post-COVID-19 syndrome patients: a randomized controlled trial.
Scientific Reports volume 13, Article number: 9473. 10 June 2023

Shani Zilberman-Itskovich, Merav Catalogna, Efrat Sasson, Karin Elman-Shina, Amir Hadanny, Erez Lang, Shachar Finci, Nir Polak, Gregory Fishlev, Calanit Korin, Ran Shorer, Yoav Parag, Marina Sova & Shai Efrati.
Hyperbaric oxygen therapy improves neurocognitive functions and symptoms of post-COVID condition: randomized controlled trial.
Scientific Reports volume 12, Article number: 11252 (2022)

Merav Catalogna, Efrat Sasson, Amir Hadanny, Yoav Parag, Shani Zilberman-Itskovich, Shai Efrati.
Effects of hyperbaric oxygen therapy on functional and structural connectivity in post-COVID-19 condition patients: A randomized, sham-controlled trial.
Neuroimage: Clinical, Volume 36, 2022, 103218

Amir Hadanny, Shachar Finci, Merav Catalogna, Ramzia Abu Hamed, Calanit Korin, Levi Gabriella, Katia Adler-Vallach, Natalia Tarasula, Mahgna Hamad, Zemer Wang, Erez Lang, Yonatan Zemel, Yair Bechor, Noami Rahimi-Levene, Yonatan Shapira, Oleg Gorelik, Irma Tzur, Eduard Ilgiyaev, Avi Mizrachi, Eli Shiloah, Yasmin Maor, Osnat Lev-Zion Korach, Shai Efrati.
Hyperbaric Oxygen Therapy for COVID-19 Patients: A Prospective, Randomized Controlled Trial.
9 Apr 2021

Traumatic Brain Injury & Post Concussion 

Amir Hadanny, Merav Catalogna, Slava Yaniv, Orit Stolar, Lynn Rothstein, Adi Shabi, Gil Suzin, Efrat Sasson, Erez Lang, Shachar Finci, Nir Polak, Gregory Fishlev, Ruth Tock Harpaz, Moran Adler, Ron-El Goldman, Yonatan Zemel, Yair Bechor & Shai Efrati
Hyperbaric oxygen therapy in children with post-concussion syndrome improves cognitive and behavioral function: a randomized controlled trial
Scientific Reports volume 12, Article number: 15223 (2022)

Boussi-Gross, R., H. Golan, G. Fishlev, Y. Bechor, O. Volkov, J. Bergan, M. Friedman, D. Hoofien, N. Shlamkovitch, E. Ben-Jacob, and S. Efrati.
Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumatic Brain Injury - Randomized Prospective Trial.
PLoS One 8, no. 11 (2013): e79995

Efrati, S. and E. Ben-Jacob.
Reflections on the Neurotherapeutic Effects of Hyperbaric Oxygen
Expert Rev Neurother 14, no. 3 (Mar 2014): 233-6

Hadanny, A., S. Abbott, G. Suzin, Y. Bechor, and S. Efrati.
Effect of Hyperbaric Oxygen Therapy on Chronic Neurocognitive Deficits of Post-Traumatic Brain Injury Patients: Retrospective Analysis.
BMJ Open 8, no. 9 (Sep 28 2018): e023387

Hadanny, A. and S. Efrati.
Treatment of Persistent Post-Concussion Syndrome Due to Mild Traumatic Brain Injury: Current Status and Future Directions.
Expert Rev Neurother 16, no. 8 (Aug 2016): 875-87

Hadanny, A., H. Golan, G. Fishlev, Y. Bechor, O. Volkov, G. Suzin, E. Ben-Jacob, and S. Efrati.
Hyperbaric Oxygen Can Induce Neuroplasticity and Improve Cognitive Functions of Patients Suffering from Anoxic Brain Damage.
Restor Neurol Neurosci 33, no. 4 (2015): 471-86

Tal, S., A. Hadanny, N. Berkovitz, E. Sasson, E. Ben-Jacob, and S. Efrati.
Hyperbaric Oxygen May Induce Angiogenesis in Patients Suffering from Prolonged Post-Concussion Syndrome Due to Traumatic Brain Injury.
Restor Neurol Neurosci 33, no. 6 (2015): 943-51

Tal, S., A. Hadanny, E. Sasson, G. Suzin, and S. Efrati.
Hyperbaric Oxygen Therapy Can Induce Angiogenesis and Regeneration of Nerve Fibers in Traumatic Brain Injury Patients.
Front Hum Neurosci 11 (2017): 508

Jacob N. Ablin ,Erez Lang, Merav Catalogna, Valerie Aloush, Amir Hadanny, Keren Doenyas-Barak, Shachar Finci, Nir Polak, Gregory Fishlev, Calanit Korin, Rachel Yehudit Tzidky, Oshra Meir Genuth, Shai Efrati.
Hyperbaric oxygen therapy compared to pharmacological intervention in fibromyalgia patients following traumatic brain injury: A randomized, controlled trial.
PloS One, March 10, 2023

Link to the Israel Society from Hyperbaric medicine and diving (ISHMD) guidelines

Post Stroke Patients

Boussi-Gross, R., H. Golan, O. Volkov, Y. Bechor, D. Hoofien, M. S. Beeri, E. Ben-Jacob, and S. Efrati.
Improvement of Memory Impairments in Post Stroke Patients by Hyperbaric Oxygen Therapy.
Neuropsychology 29, no. 4 (Jul 2015): 610-21.

Efrati, S., G. Fishlev, Y. Bechor, O. Volkov, J. Bergan, K. Kliakhandler, I. Kamiager, N. Gal, M. Friedman, E. Ben-Jacob, and H. Golan.
Hyperbaric Oxygen Induces Late Neuroplasticity in Post Stroke Patients--Randomized, Prospective Trial.
PLoS One 8, no. 1 (2013): e53716

Link to clinical guidelines and summary of stroke data from the Sagol Center for Hyperbaric Medicine and Research

Chronic Pain Syndrome - Fibromyalgia

Rahav Boussi-Gross, Merav Catalogna, Erez Lang, Zipora Shamai, Jacob N. Ablin,
Valerie Aloush, Keren Doenyas-Barak, Mordechai Lorberboym, Rachel Lev-Wiesel & Shai Efrati.
Hyperbaric oxygen therapy vs. pharmacological intervention in adults with fibromyalgia related to childhood sexual abuse: prospective, randomized clinical trial.
Nature. May 21, 2024

Jacob N. Ablin ,Erez Lang, Merav Catalogna, Valerie Aloush, Amir Hadanny, Keren Doenyas-Barak, Shachar Finci, Nir Polak, Gregory Fishlev, Calanit Korin, Rachel Yehudit Tzidky, Oshra Meir Genuth, Shai Efrati. Hyperbaric oxygen therapy compared to pharmacological intervention in fibromyalgia patients following traumatic brain injury: A randomized, controlled trial.
PloS One, March 10, 2023

Ablin, J. N., S. Efrati, and D. Buskila.
Building up the Pressure on Chronic Pain.
Clin Exp Rheumatol 34, no. 2 Suppl 96 (Mar-Apr 2016): S3-5

Efrati, S., H. Golan, Y. Bechor, Y. Faran, S. Daphna-Tekoah, G. Sekler, G. Fishlev, J. N. Ablin, J. Bergan, O. Volkov, M. Friedman, E. Ben-Jacob, and D. Buskila.
Hyperbaric Oxygen Therapy Can Diminish Fibromyalgia Syndrome-- Prospective Clinical Trial
PLoS One 10, no. 5 (2015): e0127012

Efrati, S., A. Hadanny, S. Daphna-Tekoah, Y. Bechor, K. Tiberg, N. Pik, G. Suzin, and R. Lev-Wiesel.
Recovery of Repressed Memories in Fibromyalgia Patients Treated with Hyperbaric Oxygen - Case Series Presentation and Suggested Bio-Psycho-Social Mechanism
Front Psychol 9 (2018): 848.

Hadanny, A., Y. Bechor, M. Catalogna, S. Daphna-Tekoah, T. Sigal, M. Cohenpour, R. Lev-Wiesel and S. Efrati.
Hyperbaric Oxygen Therapy Can Induce Neuroplasticity and Significant Clinical Improvement in Patients Suffering from Fibromyalgia with a History of Childhood Sexual Abuse-Randomized Controlled Trial
Front Psychol 9 (2018): 2495

Lev-Wiesel, R., Y. Bechor, S. Daphna-Tekoah, A. Hadanny, and S. Efrati.
Brain and Mind Integration: Childhood Sexual Abuse Survivors Experiencing Hyperbaric Oxygen Treatment and Psychotherapy Concurrently.
Front Psychol 9 (2018): 2535

Physical Performance & Sport

Amir Hadanny, Yafit Hachmo, Daniella Rozali, Merav Catalogna, Eldad Yaakobi, Marina Sova, Hadar Gattegno, Ramzia Abu Hamed, Erez Lang, Nir Polak, Mony Friedman, Shachar Finci, Yonatan Zemel, Yair Bechor, Noga Gal and Shai Efrati.
Effects of Hyperbaric Oxygen Therapy on Mitochondrial Respiration and Physical Performance in Middle-Aged Athletes: A Blinded, Randomized Controlled Trial
Sports Medicine - Open 8, Article number 22 (2022)

Amir Hadanny, Efrat Sasson, Laurian Copel, Malka Daniel-Kotovsky, Eldad Yaakobi, Erez Lang, Gregory Fishlev, Nir Polak, Mony Friedman, Keren Doenyas, Shachar Finci, Yonatan Zemel, Yair Bechor & Shai Efrati.
Physical enhancement of older adults using hyperbaric oxygen: a randomized controlled trial.
BMC Geriatrics, Volume 24, article number 572, (2024)

Post Traumatic Stress Disorder - PTSD

Keren Doenyas-Barak, MD; Ilan Kutz, MD; Erez Lang, MD; Amir Assouline, PhD; Amir Hadanny, MD, PhD; Kristoffer C. Aberg, PhD; Gabriela Levi, MA; Ilia Beberashvili, MD; Avi Mayo, PhD; and Shai Efrati, MD
Hyperbaric Oxygen Therapy for Veterans With Combat-Associated Posttraumatic Stress Disorder: A Randomized, Sham-Controlled Clinical.
The Journal of Clinical Psychiatry. 10 November, 2024

Gil Suzin, Keren Doenyas-Barak, Amir Hadanny, Mohammed Elamir, Roger Miller, Shai Efrati.
Hyperbaric Oxygen Therapy for Military Post-Traumatic Stress Disorder in Elderly Veterans: Case Studies, Literature Review, and Discussion.
Gavin Publishers, April 2024.

Keren Doenyas-Barak, Merav Catalogna, Ilan Kutz, Gabriela Levi, Amir Hadanny, Sigal Tal, Shir Daphna-Tekoha, Efrat Sasson, Yarden Shechter, Shai Efrati
Hyperbaric oxygen therapy improves symptoms, brain’s microstructure and functionality in veterans with treatment resistant post-traumatic stress disorder: A prospective, randomized, controlled trial.
PLOS ONE, February 22, 2022

Doenyas-Barak K, Kutz I, Levi G, Lang E, Beberashvili I, Efrati S.
Hyperbaric Oxygen Therapy for Veterans With Treatment-resistant PTSD: A Longitudinal Follow-up Study.
Mil Med. 2022 Nov 26:usac360. doi: 10.1093/milmed/usac360.

Erectile Dysfunction

Hadanny, A., E. Lang, L. Copel, O. Meir, Y. Bechor, G. Fishlev, J. Bergan, M. Friedman, A. Zisman,
and S. Efrati.
Hyperbaric Oxygen Can Induce Angiogenesis and Recover Erectile Function
Int J Impot Res 30, no. 6 (Nov 2018): 292-99.

Safety of our Treatment Protocols

Hadanny, A., O. Meir, Y. Bechor, G. Fishlev, J. Bergan, and S. Efrati.
The Safety of Hyperbaric Oxygen Treatment--Retrospective Analysis in 2,334 Patients
Undersea Hyperb Med 43, no. 2 (Mar-Apr 2016): 113-22.

Hadanny, A., O. Meir, Y. Bechor, G. Fishlev, J. Bergan, and S. Efrati.
Seizures During Hyperbaric Oxygen Therapy: Retrospective Analysis of 62,614 Treatment Sessions. Undersea Hyperb Med 43, no. 1 (Jan-Feb 2016): 21-8.